Rabies (Latin: rabies, “madness, rage, fury” also “hydrophobia”) is a viral zoon tic neuroinvasive disease that causes sharp encephalitis (irritation of the brain) in mammals.
In non-vaccinated humans, rabies is nearly invariably fatal after neurological symptoms have developed, but prompt post-exposure vaccination may avoid the virus from progressing. There are only six known cases of a person surviving symptomatic rabies, and only one known case of survival in which the patient received no rabies-specific cure either before or after illness onset.
The disease is a Lyssavirus. This genus of RNA disease also includes the Aravan virus, Australian bat lyssavirus, Duvenhage virus, European bat lyssavirus 1, European bat lyssavirus 2, Irkut virus, Khujand virus, Lagos bat virus, Mokola virus and West Caucasian bat virus. Lyssaviruses have helical symmetry, so their infectious particles are about cylindrical in shape. This is typical of plant-infecting viruses; human-infecting viruses more generally have cubic symmetry and take shapes approximating regular polyhedra. Negri bodies in the impure neurons are pathognomonic.
In non-vaccinated humans, rabies is nearly invariably fatal after neurological symptoms have developed, but prompt post-exposure vaccination may avoid the virus from progressing. There are only six known cases of a person surviving symptomatic rabies, and only one known case of survival in which the patient received no rabies-specific cure either before or after illness onset.
The disease is a Lyssavirus. This genus of RNA disease also includes the Aravan virus, Australian bat lyssavirus, Duvenhage virus, European bat lyssavirus 1, European bat lyssavirus 2, Irkut virus, Khujand virus, Lagos bat virus, Mokola virus and West Caucasian bat virus. Lyssaviruses have helical symmetry, so their infectious particles are about cylindrical in shape. This is typical of plant-infecting viruses; human-infecting viruses more generally have cubic symmetry and take shapes approximating regular polyhedra. Negri bodies in the impure neurons are pathognomonic.
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